Objective:Breast cancer is the most common cancer among women, both in Brazil and worldwide.Breast cancer can also affects men but this constitutes only 1% of cases and is thus considered rare, and for this reason is little studied.Statistics indicate an increase in its incidence with an estimate of new cases in recent years.This study aims to anal
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the standard of care texas bag ego for advanced non-small-cell lung cancer (NSCLC) patients.However, most patients will eventually develop resistance.For EGFR-TKI resistance mediated by MET amplification, the combination of EGFR and MET TKIs has shown promising results in
Abstract Mitochondrial abnormalities underscore a variety of neurologic injuries and diseases and are well-studied in adult populations.Clinical studies identify critical roles of mitochondria in a wide range of developmental brain injuries, but models that capture mitochondrial abnormalities in systems representative of the neonatal brain environm
The control of seed germination and seed dormancy are critical for the successful propagation of plant species, and are important agricultural traits.Seed germination is tightly controlled by the balance of gibberellin (GA) and abscisic acid (ABA), and gorra we are not friends is influenced by environmental factors.The COP9 Signalosome (CSN) is a c
In the midst of the national opioid crisis, it is necessary for emergency physicians and radiologists to be familiar with presentations of opioid-related complications.We describe a case report of a 51-year-old female who developed bilateral dr brown japanese maple cerebellar hemorrhages following opioid and benzodiazepine overdose.Malignant cerebe